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Genentech Halts Clinical Trial for Drug PDF Print E-mail

By PAUL ELIAS

The Associated PressWednesday, January 18, 2006; 2:57 PM

SAN FRANCISCO -- Biotechnology company Genentech Inc. has stopped a clinical trial of a promising peanut-allergy treatment because of safety concerns raised during the human experiments, a company spokesman said Tuesday.

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Teenage girl with a peanut allergy dies after kissing boyfriend PDF Print E-mail
A teenage girl with an extreme allergy has died after kissing her boyfriend who had eaten a peanut-butter sandwich hours earlier. (Source: http://www.telegraph.co.uk/news)
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Nine percent of children will outgrow their tree nut allergy: PDF Print E-mail
According to a study in the November 2005 Journal of Allergy & Clinical Immunology (JACI), approximately 9% of children with an allergy to tree nuts will outgrow their allergy, including children who have previously experienced a severe allergic reaction, The JACI is the peer-reviewed, scientific journal of the American Academy of Allergy, Asthma & Immunology (AAAAI).

Up to this point, researchers thought that allergies to tree nuts, which include cashews, almonds, walnuts, hazelnuts, macadamia nuts, pecans pistachios, and pine nuts, lasted a life time. It is estimated that 1%-2% of the United States population is allergic to peanuts, tree nuts or both. Previous research has shown that children allergic to peanuts have a 20% chance of outgrowing their allergy.

David M. Fleischer, MD, and colleagues from Johns Hopkins University School of Medicine, evaluated 278 children (Ages 3-21 years) to determine the percentage of those who will outgrow their allergy. Researchers also sought to determine what level of tree nut specific-IgE in the blood would be a safe level before testing the child through an oral food challenge, which is currently the best way to prove that a child has outgrown their food allergy.

    The study found:
  • Approximately 9% of children allergic to tree nuts outgrow their allergy, including children who have had a previous severe allergic reaction.
  • Children who are allergic to multiple types of tree nuts are unlikely to outgrow their allergy.
  • 58% of children with tree nut specific IgE levels of less than 5 kilounits per liter passed an oral challenge.

Based on these findings, researchers recommend that children with a current tree nut allergy be re-evaluated periodically by their allergist/immunologist to assess whether they have developed a tolerance and whether an oral challenge should be given.

While an ideal cut-off has not been established, researchers suggest that oral challenges should be considered in children four years and older, and who have less than five kilounits per liter of tree-nut specific IgE in their blood.

Since tree nut allergies were previously thought to last a lifetime, few patients underwent a re-evaluation to determine if their allergy still existed. They were simply told to avoid tree nuts, and were prescribed epinephrine to take in the event a severe reaction occurred. However, based on the results of the current study, it is now clear that periodic reevaluation is warranted. While only 9% will outgrow their allergy, researchers stress that it is important that these patients be identified so that they no longer need to worry about this otherwise potentially deadly allergy.

 
Bedfordshire MP attends local nut allergy group. PDF Print E-mail

Mid-Bedfordshire MP Nadine Dorries recently attended a meeting held by Flitwick based nut allergy group S.A.F.E.

During the meeting, Nadine answered a number of questions about what could be done to ensure that allergy sufferers throughout the country, are given the necessary level of health care and support.

 

Nadine went back to parliament and put the following questions to the Secretary of State for Health:

(1) what steps the Government are taking to ensure that complementary allergy practitioners are properly (a) regulated and (b) inspected; and if she will make a statement;

(2) what steps the Government have taken to ensure parents and legal guardians are appropriately trained and informed on how EpiPens should be used; and if she will make a statement;

(3) what research the Government have commissioned on changes in numbers of allergy sufferers in the last five years;

(4) what steps she is taking to improve the level of (a) training in and (b) awareness of allergies of health professionals who work in (i) primary and (ii) secondary health care; and if she will make a statement;

(5) what steps she is taking to improve (a) access to and (b) information about specialist allergy treatment; and if she will make a statement.

 

Liam Byrne (Parliamentary Under-Secretary, Department of Health) replied: 

Primary care trusts, in partnership with local stakeholders, are responsible for determining which health services their local population requires and ensuring the provision of these services.

In its response to the Health Select Committee on the provision of allergy services, the Government undertook to carry out a review of the available data and research on the epidemiology of allergic conditions, the demand for and provision of treatment and the effectiveness of relevant interventions. This review, which is being overseen by the chief medical officer and is due to report by June 2006, will inform decisions about what steps could be taken to address any service gaps and pressures that are revealed by the review.

The Government recognise that one of the key determinants of the quality of patient care is that health professionals have an appropriate level of skills and knowledge. Addressing the training needs of health professionals is, however, the responsibility of the appropriate regulatory bodies. They set standards for the pre-registration training of doctors, nurses and other health care professionals, approve the education institutions that provide the training and determine the curricula.

Post-registration training needs for NHS staff are decided against local NHS priorities, through appraisal processes and training needs analyses informed by local delivery plans and the needs of the service. Local authorities and health service providers decide how best to provide services to meet the needs of the individuals.

We have not commissioned research into the rise in incidence of allergic conditions. The independent allergy charity, Allergy UK, estimates that allergic conditions affects approximately one in four of the UK population at some time in their lives, with the numbers affected increasing by five per cent. each year.

The Government place great importance on protecting the public from potentially unsafe practitioners, and intends to take forward statutory regulation of herbal medicine and acupuncture. We encourage other currently unregulated complementary practitioners to develop their own unified systems of voluntary self-regulation. The Department have awarded a grant of £900,000 over the next three years to the Prince of Wales's Foundation for Integrated Health to work with a range of complementary health care professions to develop a voluntary self-regulation scheme.

Responsibility for educating parents and legal guardians in the use EpiPens rests with prescribing health professional. Doctors, pharmacists and other health care professionals should support parents and carers in providing information about medicines and promoting the use of information resources such as www.nhsdirect.nhs.uk/

(Source of questions & answers - http://www.theyworkforyou.com)

 
Cambridgeshire PDF Print E-mail
 
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